A jailed Murdoch must prove his innocence amid police and government corruption after the constables are ambushed, Ogden is kidnapped, and Brackenreid goes missing.
Murdoch and Watts discover fraud after a wine connoisseur is poisoned.
A recording device made by Alexander Graham Bell assists in the investigation of a murder at a dinner honoring Helen Keller.
Murdoch investigates a surgeon performing cutting-edge organ transplants.
A spate of murders staged as suicides leads Murdoch to suspect a sequential killer targeting the elderly.
In an attempt to solve a murder, Crabtree and Constable Brackenreid go undercover at a boys school.
Murdoch investigates a car accident and uncovers sinister motives.
Brackenreid begins painting again and gets the attention of a wealthy patron while investigating an artist's murder.
After obituaries are published in advance of two men's deaths, Murdoch discovers more intended victims with a member of Station House Number Four among them. He must keep them alive before their predicted demise.
Murdoch investigates a death which may have been caused by a high-speed travel device.
Murdoch and Brackenreid find some unsportsmanlike behaviour while investigating the violent death of a cricket player on the pitch.
Murdoch investigates when a statue of the Virgin Mary gifted to his church begins miraculously weeping.
When the judge of a cooking contest is poisoned, Murdoch realizes that other competitors also tasted the tainted ingredient, including Crabtree and Margaret Brackenreid.
When Theodore Roosevelt sneaks into Canada for a hunting trip, Murdoch discovers the American President is the quarry.
As Murdoch investigates a murder with connections to vaudeville entertainers Harry and Al Jolson, Watts unravels a mystery about his own family.
Crabtree goes undercover at a chess tournament to investigate the murder of a Russian master.
Murdoch and Ogden put aside a personal matter when Nate Desmond is charged with murder.
Season Finale - An argument leads Murdoch to help a man looking for his missing wife, Crabtree contemplates his future with Nina and the Station House team works on a grisly murder.